Dr. Chang Tse-wen graduated from NTHU's Department of Chemistry and the Graduate Institute of Chemistry. His master thesis, based on the research of snake venom protein crystallization was published in the international renowned "Nature", making him one of the university's legendary figures.

In 1973, he entered Harvard Medical School. After gaining a PhD, he carried out post-doctorate research on monoclonal antibodies at the Massachusetts Institute of Technology. In 1985, he joined Baylor Hospital in Boston as a professor and also established Tanox Co with Ms Tang Nanshan, engaging in bio-pharmaceutical R&D. While at the company he suffered a series of setbacks, including delays in clinical research and breach of trust by a competitor resulting in litigation which caused financial difficulties. All such difficulties were overcome with patience and perseverance.

Anti-Ig, invented by Dr. Chang, was the first bio-pharmaceutical for the effective treatment of asthma. It became well-known internationally and at one point sales reached US$1 billion per year. Dr. Change's another invention is Xolair. It is the first monoclonal antibiotic drug for treating allergies and asthma that has limited side effects but highly effective. It is expected that sales will increase every year and that it will become one of the "star" drugs.

In 1996, he returned to NTHU as a professor and served as the Dean of the College of Life Sciences. He set strict standards for his colleagues by insisting on self-motivation, pursuing academic ideals, and doing the right things. While at NTHU, he made a number of donations to allow his alma mater to purchase software and hardware for research and was a benefactor for students in many ways. After leaving NTHU, Dr. Chang was recruited as the CEO of the Development Center for Biotechnology, and served as the Technology Adviser to the Executive Yuan, as well as Distinguished Researcher in the Genomics Research Center, Academia Sinica. He is a man most directly involved in the development of Taiwan's bio-tech industry. In 2005, he made a further donation to NTHU, allowing the "Sitang" ecological area to be completed. The park is now home to various kinds of dragonflies and frogs and has a haven for beautiful butterflies.